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. 2018 Dec 14;9:2971. doi: 10.3389/fimmu.2018.02971

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Copyright © 2018 Litvinova, Darnige, Kirilovsky, Burnel, de Luna and Dragon-Durey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency of other APS non-conventional markers in the different groups of patients and HD. Non-conventional APS markers of IgG and IgM isotypes were detected by immunodot technique in sera of different groups of patients and in HD. Y ax shows a mean of positive markers (PA, PG, PI, PS, A5, and PT of IgG and IgM isotypes) per patient in each group. HD, Healthy Donors; SNAPS, seronegative anti-phospholipid syndrome; Asympt APA, asymptomatic carriers of antiphospholipid antibodies; APS 1 BM, APS with 1 biomarker; APS 2 BM, APS with 2 biomarkers; APS 3 BM, APS with 3 biomarkers; V thromb, venous thrombosis; Art thromb, arterial thrombosis; Obst APS, obstetrical APS; CAPS, Catastrophic anti-phospholipid syndrome; Pos, positive.