Table 2.

Left ventricular baseline volumetric and haemodynamic study

	Younger controls (n = 24)	Age-matched controls (n = 16)	LVT− (n = 36)	LVT+ (n = 32)	P-valuea	P-valueb	P-valuec
Volumetric assessment
Anterior infarction (n)			22	28			0.01
Infarct size (% of LV)			21 ± 14	24 ± 12			0.6
Apical RWMA score			3 ± 1	4 ± 0.5			0.055
Stroke volume (mL)	105 ± 30	93 ± 28	77 ± 26	75 ± 31	<0.01	0.06	0.42
Ejection fraction (%)	62 ± 7	64 ± 5	44 ± 11	32 ± 17	0.13	<0.01	<0.01
LVEDVi (mL/m2)	91 ± 19	75 ± 21	91 ± 16	100 ± 43	<0.01	<0.01	0.01
LVESVi (mL/m2)	35 ± 11	27 ± 6	52 ± 15	67 ± 41	<0.01	<0.01	<0.01
LVMi (g/m2)	52 ± 15	49 ± 9	56 ± 13	68 ± 21	0.44	0.03	<0.01
Haemodynamic assessment
E-wave velocity (cm/s)d	59 ± 44	48 ± 22	26 ± 9	27 ± 10	0.08	<0.01	0.66
A-wave velocity (cm/s)d	32 ± 19	34 ± 13	24 ± 8	24 ± 8	0.65	<0.01	0.21
E/A ratio	2 ± 0.6	1.3 ± 0.4	1.3 ± 0.7	1.2 ± 0.8	0.09	0.71	0.71
MDT (ms)	147 ± 35	140 ± 26	146 ± 30	137 ± 42	0.7	0.4	0.81
Mitral regurgitation (mL)	0 ± 0.01	0 ± 0.02	3 ± 4	4 ± 3	0.33	0.01	0.09

Data are presented as median ± interquartile range or count (n). LV measurements are indexed to body surface area.

LVEDVi, left ventricular end-diastolic volume (indexed); LVESVi, left ventricular end-systolic volume (indexed); LVMi, left ventricular mass (indexed); MDT, mitral deceleration time; MV, mitral valve; RWMA, regional-wall motion abnormality score (1 = normal, 2 = hypokinaesia, 3 = akinetic, 4 = diskinetic).

^aYounger controls vs. older age-matched to patient controls.

^bAge-matched controls vs. LVT−.

^cLVT− vs. LVT+.

^dThese peak inflow velocities are average peak velocities for the full mitral annular flow.