Table 3.
NET8 (rs5569), CHRNA4 (rs1044396) and CRHR1 (rs28364027) genotypes and allele frequencies between IGA and non-IGA groups
| Gene (SNP) | MAF | Genotype | IGA (n = 116) | Non-IGA (n = 114) | χ21 | p1 | Allele type | IGA (n = 116) | Non-IGA (n = 114) | χ22 | p2 | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | |||||||||
| NET8 (rs5569) | 0.25 | AA | 65 (58.6) | 70 (50.2) | 0.89 | .640 | A | 177 (76.0) | 167 (73.2) | 0.50 | .450 | 0.78 (0.47–1.32) |
| AG | 41 (35.3) | 47 (41.3) | G | 56 (24.0) | 61 (26.8) | |||||||
| GG | 7 (6.1) | 7 (6.1) | ||||||||||
| CHRNA4 (rs1044396) | 0.21 | CC | 68 (58.6) | 71 (62.3) | 0.59 | .730 | C | 180 (77.6) | 180 (78.9) | 0.10 | .730 | 1.17 (0.63–1.95) |
| CT | 44 (37.9) | 38 (33.3) | T | 52 (22.4) | 48 (21.1) | |||||||
| TT | 4 (3.5) | 5 (4.4) | ||||||||||
| CRHR1 (rs28364027) | 0.07 | AA | 107 (92.2) | 93 (81.6) | 5.76 | .016 | A | 223 (97.8) | 207 (94.7) | 5.36 | .021 | 2.63 (1.17–6.15) |
| AG | 9 (7.8) | 21 (18.4) | G | 9 (2.2) | 21 (5.3) | |||||||
| GG | 0 (0.0) | 0 (0.0) |
IGA Internet gaming addiction, non-IGA non-Internet gaming addiction, SNP single nucleotide polymorphism, MAF minor allele frequency; χ21, χ2 in comparison of genotype frequency between IGA and non-IGA; p1, p-value in comparison of genotype frequency between IGA and non-IGA; χ22, χ2 in comparison of allele frequency between IGA and non-IGA; p2, p-value in comparison of allele frequency between IGA and non-IGA; OR, odds ratio; CI, confidence interval