Fig. 2.

Schedule of evaluations. SCR screening, BL baseline – at randomisation, U/S unscheduled, TB tuberculosis, ALT alanine aminotransferase, BR bilirubin, DST drug susceptibility test, FBC full blood count, IGRA interferon-gamma release assay, WHO World Health Organization. *If intercurrent exposure to an isoniazid- or rifampicin-susceptible TB case, preventive therapy will be offered. **At selected sites only. #Based on clinical indication only – TB symptoms at baseline, or at follow-up: new or persistent symptoms, or CXR changes at any time including endpoint evaluation. HIV testing at 48 weeks will be repeated in HIV-negative participants. If HIV status is already known to be positive at screening, the CD4 count and HIV viral load should be completed at baseline in HIV-infected children. HIV viral load is standard of care in HIV-infected children