Fig. (1).

Anti-CD49d antibody injections did not affect plaque load in APP/PS1 mice. C57BL/6 and APP/PS1 mice were injected intravenously (tail-vein) with Saline, IgG isotype control (purified NA/LE Rat IgG2b) (I.C.) or 2 mg/kg purified NA/LE rat anti-mouse CD49d (anti-CD49d) once a week for 4 weeks. Right brain hemispheres from all the mice were fixed, serially sectioned, and immunostained using anti-Aβ (4G8) antibody. Representative images from 3-6 animals per group are shown at 20X magnification with 63X magnification insets. Quantitation of immunostaining was performed and O.D. values were averaged and plotted ± SD.