Fig. (2).
Anti-CD49d injections did not alter Aβ1-40 and Aβ1-42 levels in the brain. C57BL/6 and APP/PS1 mice were injected intravenously (tail-vein) with Saline, IgG isotype control (purified NA/LE Rat IgG2b) (I.C.) or 2 mg/kg purified NA/LE rat anti-mouse CD49d (anti-CD49d) once a week for 4 weeks. Part of the parietal cortex from left brain hemispheres was dissected out, lysed and used for soluble and insoluble Aβ1-42 and Aβ1-40 measurements using ELISA. Aβ levels were determined from 3-6 animals per group ± SD (*p<0.05).