Fig. (5).

Anti-CD49d injections reduced IL-12 and IFN-γ levels in the brain. C57BL/6 and APP/PS1 mice were injected intravenously (tail-vein) with Saline, IgG isotype control (purified NA/LE Rat IgG2b) (I.C.) or 2 mg/kg purified NA/LE rat anti-mouse CD49d (anti-CD49d) once a week for 4 weeks. A portion of parietal cortex from the left brain hemispheres was dissected out, lysed, and used for multiple cytokine measurements using ELISA. Cytokine levels were determined from 3-6 animals per group ± SD (*p<0.05).