Table 1.

Overview of the characteristics of PDMS breast implant surface modification methods

Modification Methods	Type	Characteristics
Roughness Modification	Smooth	Severe fibrosis, High CC incidence rate
	Textured	Surface roughness of 100–300 μm, Fixing of the implant position, Known to cause less fibrosis, ALCL
	Micro Textued	Surface roughness of 10 to 100 μm, Low CC incidence rate
Anti- adhesion barrier solution (AABS) treatment	•	Reducing inflammation and fibrosis formation
Anti-bacterial	•	Lower the incidence of CC
Plasma treatment	•	Increased wettability, Easy to functionalize
Anti-fibrosis drug coating	Triamcinolone	Glucocorticoids, Effectively suppress fibrosis and CC, Cause side effects
	Tranilast	Drug that targets TGF-β, Suppress fibrosis and CC
	Montelukast/zafirlukast	Inhibitors of Cysteinyl leukotriene (CysLTs), Suppress fibrosis and CC
	Halofuginone	Interferes with Smad3 phosphorylation in the TGF-β signaling pathway, Cause side effects, Suppress fibrosis and CC