Table 3.

Univariable and multivariable Cox regression analysis of the PCG-lncRNA signature and survival of GBM patients

Variables	Univariable analysis				Multivariable analysis
	HR	95% CI of HR		P	HR	95% CI of HR		P
		Lower	Upper			Lower	Upper
The training set
Age
> 60 vs. ≤ 60	1.54	0.9	2.64	0.12	1.96	0.98	3.92	0.06
Sex
Male vs. female	0.68	0.39	1.2	0.18	0.65	0.33	1.28	0.21
KPS
> 70 vs. ≤ 70	0.86	0.42	1.74	0.04	2.48	1.05	5.87	0.04
The signature
High risk vs. low risk	4.68	2.48	8.80	< 0.001	5.94	2.66	13.25	< 0.001
The test set
Age
> 60 vs. ≤ 60	1.93	1.05	3.56	0.04	1.66	0.81	3.44	0.16
Sex
Male vs. female	0.8	0.45	1.43	0.45	1.16	0.52	2.59	0.71
KPS
> 70 vs. ≤ 70	0.51	0.25	1.07	0.08	0.53	0.24	1.17	0.12
The signature
High risk vs. low risk	2.77	1.49	5.16	0.001	2.89	1.35	6.20	0.01
The independent set
Age
> 60 vs. ≤ 60	1.65	0.92	2.96	0.09	1.54	0.85	2.79	0.15
Sex
Male vs. female	0.92	0.53	1.61	0.77	1.05	0.59	1.85	0.88
The signature
High risk vs. low risk	2.24	1.22	4.11	0.01	2.17	1.16	4.07	0.02
The entire TCGA set
MGMT
Methylated vs. unmethylated	0.92	0.48	1.77	0.80	0.94	0.49	1.83	0.87
IDH1
R132H vs. WT	0.27	0.04	2.01	0.20	0.46	0.06	3.57	0.46
The signature
High risk vs. low risk	4.00	1.97	8.12	< 0.001	3.71	1.80	7.62	< 0.001

KPS Karnofsky performance score