Table 1.
Hematological parameters
| Hematological parameters | Group | − 24 (h) | 0 h | 3 h | 6 h | 12 h | 24 h | 48 h | 72 h | 168 h |
|---|---|---|---|---|---|---|---|---|---|---|
| WBC (/μl) | Treatment | *8240 ± 1469.01 | 13,760 ± 890.50 | *13,040 ± 1228.00 | #*12,340 ± 1377.67 | #10,740 ± 89.44 | #9940 ± 54.77 | 9580 ± 396.23 | 9240 ± 1163.18 | 8700 ± 1437.01 |
| Control | *7720 ± 810.55 | 13,160 ± 522.49 | *13,020 ± 756.30 | *12,520 ± 589.06 | *12,720 ± 1151.95 | *12,620 ± 630.07 | *12,640 ± 702.13 | *12,380 ± 690.65 | *11,740 ± 1040.67 | |
| SEG (/μl) | Treatment | *2582 ± 937.64 | 8355.20 ± 885.64 | #*7468.80 ± 1351.25 | #*6441.60 ± 279.25 | #5814 ± 541 | #5098 ± 84.81 | #3828.20 ± 246.90 | 3653.80 ± 205.11 | 3156.40 ± 1657.72 |
| Control | *2550.20 ± 843.41 | 8467.60 ± 992.59 | *8512.20 ± 599.36 | *8101.20 ± 954.74 | *7826.60 ± 1288.89 | *7739.80 ± 1000.22 | *7654.20 ± 1395.41 | *7299.40 ± 533.47 | *6676.20 ± 450.88 | |
| BAND (/μl) | Treatment | 27.4 ± 26.43 | 73 ± 56.74 | 71.6 ± 66.72 | 64 ± 58.99 | 60 ± 56.56 | 58.8 ± 38 | #55.2 ± 40 | #44 ± 36.29 | #35 ± 22.91 |
| Control | 34.8 ± 32.42 | 73.2 ± 57.99 | 77.6 ± 49.88 | 86.2 ± 52.50 | 89.2 ± 57.47 | 102 ± 63.80 | 112.8 ± 81.68 | 131.2 ± 104.88 | *174.8 ± 51.89 | |
| LYM (/μl) | Treatment | 5173.4 ± 577.66 | 3363.4 ± 900.92 | 3480.4 ± 1197.64 | 3758 ± 664.16 | 3885.8 ± 606.60 | 4120.6 ± 743.79 | 4255.2 ± 891.68 | 4509 ± 994.02 | 4906.8 ± 1015.92 |
| Control | 4852.4 ± 1214.24 | 3175.6 ± 882.11 | 3268 ± 1603.72 | 3376 ± 813.13 | 3393.6 ± 1145.60 | 3471.8 ± 1196.61 | 3596.2 ± 1301.70 | 3678.4 ± 1338.22 | 3795.8 ± 815.30 | |
| MON (/μl) | Treatment | 86 ± 5.47 | 76 ± 60.76 | 80 ± 109.54 | 78 ± 174.41 | 76 ± 66.55 | 80 ± 123.28 | 78 ± 126.17 | 78 ± 62.60 | #80 ± 77.78 |
| Control | 76 ± 4.18 | 68 ± 8.36 | 72 ± 97.31 | 78 ± 83.18 | 84 ± 85.02 | 90 ± 108.39 | 96 ± 108.30 | 100 ± 70.71 | *130 ± 12.24 | |
| RBC (×106/μl) | Treatment | 6.11 ± 0.21 | 6.23 ± 0.90 | 6.28 ± 0.78 | 6.28 ± 0.67 | 6.24 ± 1 | 6.2 ± 0.92 | #6.18 ± 0.96 | 6.13 ± 0.98 | 6.08 ± 0.99 |
| Control | 6.07 ± 0.09 | 6.21 ± 1.11 | 6.27 ± 0.91 | 6.29 ± 1.09 | 6.32 ± 0.88 | 6.32 ± 0.86 | *6.35 ± 0.09 | 6.31 ± 1.20 | 6.24 ± 1.04 | |
| Hgb (g/dl) | Treatment | 12.12 ± 0.44 | 12.44 ± 0.56 | 12.56 ± 1.56 | 12.48 ± 1.16 | 12.36 ± 0.51 | 12.34 ± 1.32 | #12.26 ± 0.94 | 12.2 ± 1.01 | 12 ± 0.57 |
| Control | 12 ± 0.18 | 12.22 ± 1.46 | 12.52 ± 1.86 | 12.72 ± 1.97 | 12.88 ± 1.6 | 12.9 ± 1.50 | *13.04 ± 0.11 | 12.86 ± 1.10 | 12.62 ± 0.52 | |
| Hct (%) | Treatment | 39.16 ± 2.24 | 40.66 ± 2.66 | 40.58 ± 3.20 | 40.46 ± 2.36 | 40.18 ± 2.43 | 40.1 ± 2.87 | 39.54 ± 2.27 | 39.3 ± 2.74 | 39.46 ± 2.08 |
| Control | 38.9 ± 2.54 | 40.4 ± 2.67 | 40.68 ± 3.29 | 40.9 ± 4.04 | 40.94 ± 4.18 | 41.02 ± 3.54 | 40.7 ± 3.45 | 40.52 ± 3.07 | 40.2 ± 3.29 | |
| Plt (×103/μl) | Treatment | 371.2 ± 87.08 | 353 ± 74.24 | 339 ± 80.56 | 347.6 ± 64.43 | 345.6 ± 58.65 | 361.8 ± 74.88 | 380.4 ± 75.92 | 374 ± 66.60 | 368.4 ± 61.05 |
| Control | 339 ± 103.84 | 330.2 ± 111.21 | 322.4 ± 78.15 | 322 ± 104.41 | 324 ± 42.95 | 316.8 ± 70.25 | 337.2 ± 64.13 | 322.8 ± 74.38 | 332.4 ± 82.26 |
Abbreviations: WBC White blood cells, SEG Segmented heterophils, BAND Band heterophils, LYM Lymphocytes, MON Monocytes, RBC Red blood cells, Hgb Hemoglobin, Hct Hematocrit, Plt Platelets
Data are presented as mean ± SD for rabbits in the treatment (acute respiratory distress syndrome [ARDS] + bone marrow mesenchymal stem cells) and control (ARDS + PBS) groups at the different time points of sampling
*p ≤ 0.05; significant compared with inflammation time in the same group
#p ≤ 0.05; significant compared with the control group at the same time