Table 3.

End organ abnormalities among patients with cytokine release syndrome

	Total patients with CRS (N = 51)
	All grades	Grades 1–2	Grades 3–4
Liver
ALT high	25 (49)	24 (47)	1 (2)
AST high	40 (78)	23 (45)	17 (33)
Bilirubin high	22 (43)	22 (43)	0
Kidney
Creatinine high	18 (35)	15 (29)	3 (6)
Pulmonary and vascular systems
Hypotension	12 (24)	9 (18)	3 (6)
Hypoxia	4 (8)	4 (8)	0
Respiratory failure	1 (2)	0	1 (2)
Coagulopathya
aPTT prolonged	31 (67)	28 (61)	3 (7)
Fibrinogen decreased	17 (37)	0	17 (37)

ALT alanine aminotransferase, aPTT activated partial thromboplastin time, AST aspartate aminotransferase, CRS cytokine release syndrome

^aOnly 46 patients had laboratory test results available (N = 46 was used as the denominator)