Fig. 1.

Exome sequencing and transcriptomic analysis identified BMP5 as novel tumor suppressor gene in sCRC. a Sketch map of LoF mutations in 3 sCRC samples. Outer circle represents the distribution of mutation on each chromosome, and inner circle represents the quantity and proportion of three types of mutations. b Distribution of 72 somatic mutations in 3 samples. c Systematic analysis of 71 genes at system-level and selection of top rank gene BMP5 in this study. d Deep sequencing of BMP5 coding regions identified novel somatic mutations in sCRC samples. Relative positions of mutations are indicated by symbols. Stars, nonsense; Triangles, missense; Dots, synonymous. e Genetic alteration analysis of BMP5 in seven solid tumors