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. 2018 Dec 20;13:66. doi: 10.1186/s13024-018-0298-9

Table 1.

Summary of the major findings on TREM2 in AD context

AD context Major TREM2-AD related findings Source Citations
Risk factors ❖ Rare variants in TREM2 increase LOAD risk by 2- to 4- fold AD patients [104, 107118]
Amyloid pathology ❖ Loss of functional TREM2 decreases microgliosis around plaques 5xFAD mice
APPPS1-21 mice
[45, 75, 130, 132, 133]
❖ Loss of functional TREM2 decreases plaque compaction 5xFAD mice
APPPS1-21 mice
[75, 89, 90, 133]
Tau pathology ❖ TREM2 deletion decreases tau-mediated neurodegeneration PS19 mice [152, 153]
❖ TREM2 deletion (1) or haploinsuficiency (2) increase tau pathology hTau mice (1)
PS19 mice (2)
[151] (1)
[153] (2)
ApoE ❖ ApoE is a TREM2 ligand in vitro [76, 78, 79]
❖ ApoE-induced switch from homeostatic to neurodegenerative microglia is TREM2-dependent APPPS1-21 mice [95]