Fig. 1.

Identification of the down-regulated expression profile of miR-133a-3p in GC tissues from TCGA database. (a) 319 differentially expressed miRNAs according to TCGA miR-seq with fold-changes greater than 2.0 were showed by volcano plots. (b). The cluster heat map which demonstrates the top 40 differentially expressed miRNA. Rows represent circRNAs while columns represent tissues. (c). The top 10 downregulated and top 10 upregulated miRNAs were listed. (d). Expression pattern of miR-133a-3p from TCGA miR-seq. (e).qRT-PCR assay among 80 patients showed the consistent results with the database. (f). Overall survival(OS) and disease-free survival (DFS) curves were plotted by KaplaneMeier analysis according to the circNRIP1 expression level. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001