Table 4.

Classification of risk factors for venous thrombosis at baseline

	Subgroup	Requirement
Provoked by persistent risk factor
Active cancer – n (%)	• Hematologic malignancies • Solid tumors	Diagnosed, or treated within 3 months, or presence of metastases
Major organ disease – n (%)	• Cardiac • Gastrointestinal • Renal • Neurological	Exclude major infectious disease
Major congenital venous anomaly – n (%)		Venous anomaly in relation to location of index event
Known inherited thrombophilia – n (%) • Antithrombin, protein C or protein S deficiency • Factor V Leiden, or prothrombin mutation	• Homozygous • Heterozygous	At baseline or confirmed after randomization
Acquired thrombophilia – n (%)		Antiphospholipid syndrome. At baseline or confirmed after randomization
Family history of venous thrombosis – n (%)		First degree (parent or sibling)
Morbid obesity – n (%)		Body mass index > 35 kg/m2
Provoked by transient risk factor
Major surgery – n (%)		Timeframe: within 1 month
Major trauma – n (%)		Timeframe: within 1 month
Major infectious disease – n (%)	• Systemic • Local	Timeframe: within 1 month Local infection in anatomical relation with index event
Prolonged immobilization – n (%)		Timeframe: within 1 month Duration immobilization > 1 week
Central venous catheter – n (%)		Timeframe: within 1 month Location of index event related to central venous catheter
Use of estrogens or progestins – n (%)
Puerperium– n (%)		Puerperium ends 6 weeks after birth
Etiology of index venous thrombosis
Unprovoked – n (%)  Provoked by persistent risk factor – n (%)  Provoked by transient risk factor – n (%)  Provoked by persistent and transient risk factor – n (%)
Number of risk factors – n (%)  0  1  ≥2