Table 3.

Baseline and longitudinal associations between log-transformed inflammatory biomarkers and epigenetic age acceleration

	IEAA*			EEAA†
	Standardised beta	SE	p	Standardised beta	SE	p
Baseline
Low-sensitivity CRP	0.057	0.033	0.087	0.154	0.034	2.48 × 10−5
High-sensitivity CRP	0.047	0.036	0.189	0.111	0.037	0.004
IL-6	0.021	0.036	0.563	0.114	0.037	0.003
Low-sensitivity CRP ≤ 10 mg/L	0.062	0.035	0.081	0.129	0.039	0.0009
Longitudinal
Low-sensitivity CRP	−0.017	0.019	0.360	−0.008	0.019	0.672
High-sensitivity CRP	0.005	0.039	0.888	−0.006	0.039	0.888
IL-6	0.034	0.041	0.392	0.009	0.042	0.829
Low-sensitivity CRP ≤ 10 mg/L	−0.020	0.020	0.303	−0.006	0.020	0.759

CRP C-reactive protein, IL-6 interleukin 6

*Intrinsic epigenetic age acceleration

†Extrinsic epigenetic age acceleration