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. 2018 Dec 13;68(1):3–14. doi: 10.2337/dbi18-0035

Figure 2.

Figure 2

Role of GLUT4 in regulating whole-body glucose tolerance and insulin sensitivity. GLUT4 protein levels are decreased in white adipose tissue but not in skeletal muscle, of insulin-resistant humans and rodents (A). Adipose-specific overexpression of GLUT4 (AG4OX) lowers fasting glycemia and improves whole-body glucose tolerance (B), whereas adipose-specific GLUT4 deletion (AG4KO) causes whole-body glucose intolerance (C) and insulin resistance (D–F). Adipose-specific GLUT4 deletion causes liver insulin resistance (E) and decreases glucose uptake in adipose tissue and skeletal muscle (F). For experimental details for panel B, see Carvalho et al. (4). For experimental details for panels C–F, see Abel et al. (5). Panel B reprinted from Carvalho et al. (4). Panels C–F reprinted from Abel et al. (5). *Panels B–D and F: P < 0.05 vs. control; panel E: P < 0.05 vs. control + insulin. BAT, brown adipose tissue; Con, control; GTT, glucose tolerance test; ITT, insulin tolerance test; WAT, white adipose tissue.