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Microarray analysis of adipose tissue from adipose-specific GLUT4 knockout and adipose-specific GLUT4 overexpressor mice. White adipose tissue from these genetically modified mice was subjected to Affymetrix DNA array analysis. This led to the identification of GLUT4-dependent genes, which have systemic effects on insulin sensitivity. Examples are RBP4, the major protein transporting retinol in the blood, and ChREBP, a transcription factor that regulates lipogenesis and glycolysis.
