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Role of RBP4 in regulating whole-body insulin sensitivity. A: Serum RBP4 levels correlate with multiple components of the metabolic syndrome. B: RBP4-induced activation of antigen-presenting cells in adipose tissue is sufficient to cause adipose “inflammation” and systemic insulin resistance. Panel B reprinted from Moraes-Vieira et al. (25). Trig., triglycerides.
