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. 2018 Dec 11;25(11):3047–3058.e4. doi: 10.1016/j.celrep.2018.11.043

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Intracellular Lactate Accumulation Is due to Inhibition of the Lactate Transporters MCT1 and MCT4 by Syrosingopine

(A–C) Intracellular lactate accumulation in HAP1 cells deleted for MCT1 (A), MCT4 (B), and HAP1 wild-type cells (C) following treatment with ARC155858 (1 μM), syrosingopine (10 μM), or F3-syro (10 μM).

(D–F) Dose-responsive increase in intracellular lactate in HAP1 cells deleted for MCT1 (D), MCT4 (E), and HAP1 wild-type cells (F) treated with ARC155858, syrosingopine, and F3-syro for 2 hrs. Each assay was performed twice and a representative experiment is shown. Data points performed in duplicate and presented as mean ± SEM.