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Syrosingopine Inhibits Lactate Efflux by MCT1 and MCT4
Lactate export assays showing amount of radiolabeled lactate (cpm) retained in the cell pellet versus label released into the medium over a time course for HAP1 MCT4-KO cells pre-treated with indicated drugs (syrosingopine, 10 μM; F3-syro, 1 μM; and ARC155858, 10 μM) (A). Similar assays were performed for HAP1 MCT1-KO cells (B) and HL60 cells (C). Each assay was performed at least twice and a representative experiment is shown.
