REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal MCT1	Santa Cruz	sc50324; RRID: AB_2189197
Mouse monoclonal MCT1	Santa Cruz	sc365501; RRID: AB_10841766
Rabbit polyclonal MCT2	Santa Cruz	sc50322; RRID: AB_2187242
Rabbit polyclonal MCT3	Abcam	ab60333; RRID AB_944129
Rabbit polyclonal MCT4	Santa Cruz	sc50329; RRID AB_2189333
Mouse monoclonal MCT4	Santa Cruz	sc376140; RRID AB_10992036
Mouse monoclonal CD147	R&D	MAB972; RRID AB_2066679
Rabbit polyclonal CD147	Abcam	ab64616; RRID AB_1603445
Rabbit polyclonal GAPDH	Abcam	ab9385; RRID AB_449791
Mouse monoclonal β1-integrin	Santa Cruz	sc374430; RRID AB_10991321
Chemicals, Peptides, and Recombinant Proteins
Syrosingopine	Extrasynthese	#1691; CAS 84-36-6
F3-Syro	Custom synthesis	N/A
Syro-D	Custom synthesis	N/A
Reserpine	Sigma-Aldrich	R0875; CAS 50-55-5
ARC155858	Tocris	CAS 496791-37-8
Sodium oxamate	Sigma-Aldrich	O2751; CAS 565-73-1
Vitamin K2	Sigma-Aldrich	V9378; CAS 863-61-6
NAD free acid	Sigma-Aldrich	NAD100-RO; CAS 53-84-9
β-NMN	Sigma-Aldrich	N3501; CAS 1094-61-7
Metformin	Sigma-Aldrich	D150959; CAS 1115-70-4
Antimycin A	Sigma-Aldrich	A8674; CAS 1397-84-0
Sodium fluoride	Sigma-Aldrich	S7920; CAS 7681-49-4
Sodium Lactate, L-[2-3H], 10-20Ci/mmol	American Radiolabeled Chemicals	ART 0430
Resazurin	Sigma-Aldrich	R7017; CAS 62758-13-8
Critical Commercial Assays
Arkray Lactate Pro 2 lactate test meter	ArkRay	LT-1730
pHrodo Red AM Intracellular pH Indicator	Thermo Fisher Scientific	P35372
NAD+/NADH Quantification Colorimetric kit	BioVision	K337-100
CellTiterGlo Luminescent Assay	Promega	G7570
Lactate-Glo Luminescent Assay	Promega	J5022
Experimental Models: Cell Lines
HAP1 wild-type	Horizon Discovery	wt line C631
HAP1 MCT1-KO cl2	Horizon Discovery	HZGHC002882c002
HAP1 MCT1-KO cl10	Horizon Discovery	HZGHC002882c010
HAP1 MCT4-KO cl1	Horizon Discovery	HZGHC001844c001
HAP1 MCT4-KO cl10	Horizon Discovery	HZGHC001844c010
HeLa	ATCC	CCL-2
HCT116	ATCC	CCL-247
HL60	DSMZ	ACC-3
K562	DSMZ	ACC-10
SkBr3	Laboratory of Nancy Hynes, FMI, Basel	N/A
MDA-MD-453	Laboratory of Nancy Hynes, FMI, Basel	N/A
Experimental Models: Organisms/Strains
Mouse: Male, 20 week old Liver-specific Tsc1/Pten double knock-out in mixed C57BL/6J,129/SvJae,BALB/cJ background.	Michael Hall Laboratory (Hindupur et al., 2018)	N/A
Software and Algorithms
Prism 7	GraphPad Software	Version 7.0d