Table 1. Possible mammalian adaptation related to amino acid substitutions in CIV H3N2, China, 2016–2017*.
| Category |
Virus protein, amino acid position, amino acid (frequency, %) |
||||
|---|---|---|---|---|---|
| Polymerase basic 2 |
|
Hemagglutinin | |||
| 251 |
590 |
146 |
242 |
||
| CIV H3N2, 2006–2015 | K (89.19), R† (8.11), G (2.70) | G (100) | G (91.89), S (8.11) | V (100) | |
| CIV H3N2, 2016–2017 | R† (100) | S† (100) | S (100) | I (100) | |
| Influenza virus A(H3N2) in humans | R† (99.82), K (0.14), G (0.04) | S† (89.76), G (10.06), N (0.14), T (0.04), R (0.01) | S (99.57), G (0.42), F (0.01) | I (99.29), V (0.39), M (0.20), T (0.08), L (0.03), K (0.02) | |
| Influenza A(H1N1)pdm09 virus | R† (98.99), K (0.99), I (0.02) | S† (99.43), N (0.35), G (0.22) | K (99.64), N (0.23), R (0.07), E (0.06) | F (99.99), L (0.01) | |
*CIV, canine influenza virus. †Known determinant for adaptation to mammals.