Table 2.
Univariate and multivariate analysis of factors influencing patients’ DFS.
| Factors | Median DFS (months) | Log-rank P value | Cox P value | HR (95%CI) |
|---|---|---|---|---|
| Sex | 0.636 | |||
| Male | 38.3 | |||
| Female | 36.7 | |||
| Age | 0.328 | |||
| <60 | 37.5 | |||
| ≥60 | 35.4 | |||
| Pre-treatment serum ALP | 0.001 | 0.021 | 2.035 (1.264~2.927) | |
| Normal | 42.1 | |||
| Elevated | 32.8 | |||
| Tumor site | 0.857 | |||
| Upper | 37.7 | |||
| Middle | 36.9 | |||
| Low | 38.2 | |||
| Tmuor diameter | 0.025 | 0.146 | 1.172 (0. 718~1.684) | |
| <3 | 39.6 | |||
| ≥3 | 34.3 | |||
| T classification | <0.001 | 0.030 | 1.615 (1.048~2.579) | |
| T1 | 48.7 | |||
| T2 | 41.4 | |||
| T3 | 33.8 | |||
| T4 | 31.5 | |||
| N classification | 0.003 | 0.086 | 1.368 (0.932~1.827) | |
| N0 | 47.9 | |||
| N1 | 42.6 | |||
| N2 | 36.2 | |||
| N3 | 30.3 | |||
| TNM stage | 0.027 | 0.017 | 3.746 (1.622~6.854) | |
| I | 48.4 | |||
| II | 39.7 | |||
| III | 32.5 | |||
| Differentiation | 0.016 | 0.008 | 4.192 (2.318~6.536) | |
| Moderate and high | 44.8 | |||
| Poor | 29.1 | |||
| Pathological type | <0.001 | <0.001 | 6.804 (3.573~10.495) | |
| Adenocarcinoma | 38.6 | |||
| Signet cell carcinoma | 25.2 | |||
| Neoadjuvant chemotherapy | 0.043 | 0.794 | 0.815 (0.572~1.358) | |
| Yes | 35.4 | |||
| No | 39.1 | |||
| Postoperative chemotherapy | 0.520 | |||
| ≤3 cycles | 37.3 | |||
| ≥4 cycles | 38.5 |