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(A) Silencing of Sirt1 mitigated the beneficial impact of aerobic exercise training against diabetes-associated renal damage in diabetic mice. The proportion of the fibrosis density (%) (B) and the level of urinary protein/creatine (C) were measured in sed-control, sed-diabetes, and aex-diabetes mice in control siRNA or Sirt1 siRNA. Bar charts represent means ±SEM (n=7). ** P<0.01 vs. Sed-Control; ## P<0.01 vs. Sed-Diabetes; $$ P<0.01 vs. Aex-Diabetes.
