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. 2018 Dec 14;9:2857. doi: 10.3389/fimmu.2018.02857

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Copyright © 2018 Giovannone, Antonopoulos, Liang, Geddes Sweeney, Kudelka, King, Lee, Cummings, Dell, Barthel, Widlund, Haslam and Dimitroff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of O-glycan complexity with differentiation is associated with downregulation of the Core 2 branching enzyme GCNT1. (A) Relative mean GCNT1 expression in peripheral blood cells, analyzed from the publicly available dataset GSE24759. Box and whiskers depict minimum value, maximum value, median, and interquartile range. (B) qRT-PCR analysis of transcript levels of GCNT1 in primary tonsil and peripheral blood B cell subsets. Data were normalized to the housekeeping gene VCP and are depicted relative to naïve B cells. For (B), n = 3 distinct tonsil or peripheral blood specimens. Bars and error bars in (B) depict mean and SEM. ^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001. N, naïve; GC, germinal center; M, memory; PB, plasmablast.