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. 2018 Dec 18;15:15–22. doi: 10.2147/TCRM.S182858

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Percent changes of serum tartrate-resistant acid phosphatase (TRACP)-5b (A), urinary cross-linked N-terminal telopeptide of type I collagen (NTX) (B), serum bone alkaline phosphatase (BAP) (C), and serum 25-hydroxyvitamin D (25(OH)D) (D) at 12, 24, and 36 months (M). Circles show the denosumab group and triangles show the combination group.

Notes: Double hashtags indicate a significant difference (P<0.01) between the denosumab and combination groups. Single and double asterisks indicate a significant difference (P<0.05 and P<0.01, respectively) with baseline values.