Table S1.
Univariate analysis of clinicopathological characteristics according to the lymph node involvement
| Variables, n (%) | Total | Epithelial cell-negative group | ||||
|---|---|---|---|---|---|---|
| Node-negative group (n=282) | Node-positive group (n=440) | P-value | Node-negative group (n=185) | Node-positive group (n=333) | P-value | |
| Periostin in epithelial cell or expression level in stroma | <0.001 | 0.002 | ||||
| Negative or low level | 185 (72.3) | 333 (83.7) | 111 (60.3) | 245 (73.6) | ||
| Positive or high level | 71 (27.7) | 65 (16.3) | 73 (39.7) | 88 (26.4) | ||
| Gender | 0.776 | 0.834 | ||||
| Male | 204 (72.3) | 314 (71.4) | 126 (68.5) | 231 (69.4) | ||
| Female | 78 (27.7) | 126 (28.6) | 58 (31.5) | 102 (30.6) | ||
| Age | 0.881 | 0.928 | ||||
| <60 | 145 (52.0) | 227 (52.5) | 99 (54.1) | 175 (53.7) | ||
| ≥60 | 134 (48.0) | 205 (47.5) | 84 (45.9) | 151 (46.3) | ||
| Diameter (cm) | <0.001 | <0.001 | ||||
| <4 | 199 (71.3) | 135 (30.8) | 131 (72.0) | 101 (30.4) | ||
| ≥4 | 80 (28.7) | 304 (69.2) | 51 (28.0) | 231 (69.6) | ||
| Lauren type | <0.001 | <0.001 | ||||
| Intestinal type | 162 (63.0) | 170 (41.2) | 107 (59.4) | 132 (39.8) | ||
| Diffuse type | 95 (37.0) | 243 (58.8) | 73 (40.6) | 200 (60.2) | ||
| Serum CEA (ng/mL) | <0.001 | <0.001 | ||||
| <5 | 247 (91.5) | 305 (74.0) | 166 (93.8) | 240 (76.4) | ||
| ≥5 | 23 (8.5) | 107 (26.0) | 11 (6.2) | 74 (23.6) | ||
| Serum CA19-9 (U/mL) | <0.001 | <0.001 | ||||
| <37 | 240 (93.0) | 310 (78.5) | 156 (92.3) | 237 (79.0) | ||
| ≥37 | 18 (7.0) | 85 (21.5) | 13 (7.7) | 63 (21.0) | ||
| Serum CA72-4 (U/mL) | <0.001 | 0.002 | ||||
| <6.9 | 171 (88.1) | 234 (72.9) | 111 (87.4) | 183 (73.5) | ||
| ≥6.9 | 23 (11.9) | 87 (27.1) | 16 (12.6) | 66 (26.5) | ||
| Depth of invasion | <0.001 | <0.001 | ||||
| T0+T1+T2 | 193 (68.7) | 75 (17.1) | 120 (65.2) | 56 (16.8) | ||
| T3+T4 | 88 (31.3) | 364 (82.9) | 64 (34.8) | 277 (83.2) | ||
| Differentiation status | <0.001 | <0.001 | ||||
| Well and moderate | 112 (46.3) | 112 (26.7) | 68 (43.0) | 78 (24.9) | ||
| Poor and undifferentiated | 130 (53.7) | 307 (73.3) | 90 (57.0) | 235 (75.1) | ||
Abbreviations: CA19-9, carbohydrate antigen 19-9; CA72-4, carbohydrate antigen 72-4; CEA, carcinoembryonic antigen.