Table S2.

Cox regression analysis of periostin expression in epithelial cell according to the overall survival in patients with intestinal type gastric cancer

Variables	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Periostin expression in epithelial cell (positive vs negative)	0.505 (0.306–0.831)	0.007	0.884 (0.454–1.724)	0.718
Adjuvant chemotherapy (yes vs no)	3.472 (2.109–5.716)	<0.001	1.405 (0.714–2.762)	0.325
Serum CEA (ng/mL; ≥5 vs <5)	2.646 (1.733–4.042)	<0.001	1.077 (0.581–1.997)	0.814
Serum CA19-9 (U/mL; ≥37 vs <37)	2.555 (1.633–3.999)	<0.001	1.535 (0.825–2.765)	0.154
Serum CA72-4 (U/mL; ≥6.9 vs <6.9)	1.945 (1.157–3.268)	0.012	1.098 (0.617–1.956)	0.750
Diameter (cm; ≥4 vs <4)	4.408 (2.838–6.848)	<0.001	2.228 (1.213–4.091)	0.010
Depth of invasion (T3+T4 vs T0+T1+T2)	7.999 (4.546–14.075)	<0.001	3.220 (1.278–8.111)	0.013
Lymph node involvement (yes vs no)	7.094 (4.156–12.109)	<0.001	3.917 (1.499–10.231)	0.005
TNM stage (III+IV vs 0+I+II)	6.302 (4.071–9.756)	<0.001	0.589 (0.240–1.445)	0.247
Differentiation grade (poorly vs well+moderately)	1.434 (0.967–2.127)	0.073	1.291 (0.771–2.159)	0.331

Abbreviations: CA19-9, carbohydrate antigen 19-9; CA72-4, carbohydrate antigen 72-4; CEA, carcinoembryonic antigen.