Table S3.

Cox regression analysis of periostin expression in stroma according to the overall survival in the epithelial cell-negative patients with intestinal gastric cancer

Variables	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Periostin expression in stroma (high level vs low level)	0.561 (0.344–0.913)	0.020	0.696 (0.381–1.270)	0.237
Adjuvant chemotherapy (yes vs no)	3.124 (1.809–5.395)	<0.001	1.543 (0.729–3.265)	0.257
Serum CEA (ng/mL; ≥ 5 vs <5)	3.071 (1.917–4.920)	<0.001	1.369 (0.704–2.665)	0.355
Serum CA19-9 (U/mL; ≥37 vs <37)	2.349 (1.429–3.859)	0.001	1.497 (0.777–2.886)	0.228
Serum CA72-4 (U/mL; ≥6.9 vs <6.9)	1.638 (0.911–2.944)	0.099	0.997 (0.520–1.911)	0.994
Diameter (cm; ≥ 4 vs <4)	3.999 (2.469–6.479)	<0.001	1.949 (1.014–3.746)	0.045
Depth of invasion (T3+T4 vs T0+T1+T2)	6.032 (3.331–10.922)	<0.001	2.162 (0.838–5.581)	0.111
Lymph node involvement (yes vs no)	4.856 (2.771–8.508)	<0.001	2.716 (0.980–7.523)	0.055
TNM stage (III+IV vs 0+I+II)	4.633 (2.890–7.427)	<0.001	0.710 (0.270–1.867)	0.487
Differentiation grade (poorly vs well+moderately)	1.249 (0.803–1.941)	0.324	1.347 (0.765–2.372)	0.302

Abbreviations: CA19-9, carbohydrate antigen 19-9; CA72-4, carbohydrate antigen 72-4; CEA, carcinoembryonic antigen.