Table 2.
Susceptibility of carbapenem-resistant K. pneumoniae strains isolated from respiratory and intestinal tract of ICU patients to commonly used antibiotics
| Antibiotic | Respiratory tract+intestinal tract (n=55) | Respiratory tract (n=25) | Intestinal tract (n=30) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||||
| Range | MIC50 | MIC90 | S% | I% | R% | MIC50 | MIC90 | S% | I% | R% | MIC50 | MIC90 | S% | I% | R% | |
|
| ||||||||||||||||
| IMP | 4–128 | 64 | 64 | 0 | 0 | 100 | 64 | 64 | 0 | 0 | 100 | 32 | 64 | 0 | 0 | 100 |
| MEM | 8–>128 | 128 | >128 | 0 | 0 | 100 | 128 | >128 | 0 | 0 | 100 | 64 | >128 | 0 | 0 | 100 |
| ETP | 16–>128 | >128 | >128 | 0 | 0 | 100 | >128 | >128 | 0 | 0 | 100 | 64 | >128 | 0 | 0 | 100 |
| CMZ | 4–>128 | 128 | >128 | 21.8 | 7.3 | 70.9 | 128 | >128 | 8 | 4 | 88 | 64 | >128 | 33.33 | 10.00 | 56.67 |
| CAZ | 8–>128 | 128 | >128 | 0 | 5.5 | 94.6 | >128 | >128 | 0 | 4 | 96 | 64 | >128 | 0 | 6.67 | 93.33 |
| CTX | 64–>128 | >128 | >128 | 0 | 0 | 100 | >128 | >128 | 0 | 0 | 100 | >128 | >128 | 0 | 0 | 100 |
| TZP | 256/4–>256/4 | >256/4 | >256/4 | 0 | 0 | 100 | >256/4 | >256/4 | 0 | 0 | 100 | >256/4 | >256/4 | 0 | 0 | 100 |
| SCF | 64/32–>256/128 | >256/128 | >256/128 | 0 | 0 | 100 | >256/128 | >256/128 | 0 | 0 | 100 | >256/128 | >256/128 | 0 | 0 | 100 |
| CAV | ≤0.5/4–>64/4 | 1/4 | 4/4 | 96.4 | 0 | 3.6 | 2/4 | 4/4 | 100 | 0 | 0 | 1/4 | 4/4 | 93.33 | 0 | 6.67 |
| FEP | 32–>64 | >64 | >64 | 0 | 0 | 100 | >64 | >64 | 0 | 0 | 100 | >64 | >64 | 0 | 0 | 100 |
| PB | ≤0.5–2 | ≤0.5 | 2 | 70.9 | 29.1 | 0 | 1 | 2 | 64.00 | 36.00 | 0 | ≤0.5 | 2 | 76.67 | 23.33 | 0 |
| TGC | ≤0.25–2 | 1 | 2 | 100 | 0 | 0 | 1 | 2 | 100 | 0 | 0 | 0.5 | 2 | 100 | 0 | 0 |
| CIP | ≤1–>32 | >32 | >32 | 10.9 | 0 | 89.1 | >32 | >32 | 4.00 | 0 | 96 | >32 | >32 | 16.67 | 0 | 83.33 |
| AK | ≤4–>128 | >128 | >128 | 25.5 | 0 | 74.6 | >128 | >128 | 12.00 | 0 | 88.00 | >128 | >128 | 36.67 | 0 | 63.33 |
| ATM | ≤4–>128 | >128 | >128 | 1.8 | 0 | 98.2 | >128 | >128 | 0 | 0 | 100 | >128 | >128 | 3.33 | 0 | 96.67 |
Abbreviations: AK, amikacin; ATM, aztreonam; CAV, ceftazidime/avibactam; FEP: cefepime; PB: polymyxin B; CIP, ciprofloxacin; CMZ, cefmetazole; CAZ: ceftazidime; CTX: cefotaxime; TZP: piperacillin/tazobactam; SCF: cefoperazones/sulbactam; ETP, ertapenem; ICU, intensive care unit; IMP, imipenem; MIC, minimum inhibitory concentration; MEM, meropenem; TGC, tigecycline.