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. 2018 Dec 18;14:17–32. doi: 10.2147/IJN.S175340

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© 2019 Xu et al. This work is published and licensed by Dove Medical Press Limited

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In vitro viability of three types of gastric cancer cells treated with blank NPs, PEG-PCL, PEG-PCL-IgG, PEG-PCL-mAb, free DOC, DOC-PEG-PCL, DOC-PEG-PCL-IgG, and DOC-PEG-PCL-mAb NPs at different drug concentrations after 48 hours of incubation.

Notes: (A) PD-L1 expression level of MGC803, MKN45, and HGC27 cells before and after PD-L1 plasmid transfection by flow cytometry and Western blot analysis. (B) In vitro viability of three kinds of gastric cancer cells. Data were expressed as the mean±SD of three independent experiments. ***P<0.005, **P<0.01, and *P<0.05 were considered significant.

Abbreviations: APC, allophycocyanin; DOC, docetaxel; IgG, Immunoglobulin G; mAb, monoclonal antibody; NP, nanoparticle; PD-L1, programmed death-ligand 1; PEG-PCL, poly (ethylene glycol)-poly (ε-caprolactone).

In vitro viability of three types of gastric cancer cells treated with blank NPs, PEG-PCL, PEG-PCL-IgG, PEG-PCL-mAb, free DOC, DOC-PEG-PCL, DOC-PEG-PCL-IgG, and DOC-PEG-PCL-mAb NPs at different drug concentrations after 48 hours of incubation.

Notes: (A) PD-L1 expression level of MGC803, MKN45, and HGC27 cells before and after PD-L1 plasmid transfection by flow cytometry and Western blot analysis. (B) In vitro viability of three kinds of gastric cancer cells. Data were expressed as the mean±SD of three independent experiments. ***P<0.005, **P<0.01, and *P<0.05 were considered significant.

Abbreviations: APC, allophycocyanin; DOC, docetaxel; IgG, Immunoglobulin G; mAb, monoclonal antibody; NP, nanoparticle; PD-L1, programmed death-ligand 1; PEG-PCL, poly (ethylene glycol)-poly (ε-caprolactone).