Table 1.
Ratio of PEG-PCL to PD-L1 mAb (% w/w) | PD-L1 mAb content (% w/w) |
---|---|
10 | 4.2±0.23 |
20 | 9.7±0.55 |
30 | 17.6±1.21 |
40 | 22.5±0.83 |
50 | 23.1±1.43 |
60 | 22.8±1.62 |
Note: 40% weight ratio (w/w) of PEG-PCL/PD-L1 mAb was the best choice to synthesize PEG-PCL-mAb copolymers.
Abbreviations: mAb, monoclonal antibody; NP, nanoparticle; PD-L1, programmed death-ligand 1; PEG-PCL, poly (ethylene glycol)-poly (ε-caprolactone).