Table 1.
MIC distribution of Yarrowia lipolytica isolates
| Antifungal classes | Antifungal agent | Number of isolates with MIC (µg/ml) of | MIC50* | MIC90* | Observations | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.008 | 0.016 | 0.032 | 0.064 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥ 64 | |||||
| Polyene antifungals | Amphotericin B | 7 | 22 | 19 | 6 | 4 | 1 | 1 | 2 | 59 | ||||||||
| Azole antifungals | Ketoconazole | 1 | 3 | 3 | 4 | – | – | 11 | ||||||||||
| Fluconazole | 1 | 2 | 3 | 14 | 15 | 1 | 2 | 5 | 8 | 4 | > 64 | 51 | ||||||
| Itraconazole | 1 | 2 | 1 | 7 | 16 | 3 | 1 | 3 | 0.5 | 2 | 34 | |||||||
| Posaconazole | 1 | 3 | 3 | 12 | 5 | 4 | 1 | 3 | 0.5 | 4 | 32 | |||||||
| Voriconazole | 1 | 1 | 9 | 9 | 5 | 2 | 4 | 4 | 0.064 | 2 | 35 | |||||||
| Echinocandins | Anidulafungin | 3 | 7 | 5 | 6 | 2 | 1 | – | – | 24 | ||||||||
| Caspofungin | 1 | 1 | 7 | 12 | 9 | 1 | 0.25 | 0.5 | 31 | |||||||||
| Micafungin | 1 | 2 | 8 | 8 | 5 | – | – | 24 | ||||||||||
| Others | 5-Fluorocytosine | 1 | 3 | 4 | 3 | 6 | – | – | 17 | |||||||||
*MIC50 and MIC90 values were calculated for antifungals with at least 30 observations