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. 2018 Aug 8;9(12):3153–3165. doi: 10.1021/acschemneuro.8b00337

Figure 1.

Figure 1

External application of BL-1249 selectively activates mechanosensitive K2P channels. (A) Exemplar current traces for specified K2P channels (black) with 10 μM BL-1249 (light blue) as measured via TEVC in Xenopus oocytes. (B) K2P channel phylogenetic tree. Stars denote assayed representative K2P channels. Blue stars indicate BL-1249 responsive channels. (C) BL-1249 dose–response curves for K2P2.1(TREK-1) (blue circles), K2P10.1(TREK-2) (black triangles), and K2P4.1(TRAAK) (orange squares). EC50 = 5.5 ± 1.2 μM, 8.0 ± 0.8 μM, and 48 ± 10 μM, respectively. (D) BL-1249 responses of indicated K2P channels. Inset shows expanded view of poorly responsive K2P channels. Error bars are SEM.