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. 2018 Nov 15;3(22):e121932. doi: 10.1172/jci.insight.121932

Figure 6. Patients with microsatellite instability have greater infiltration and engagement of cytotoxic T lymphocytes in the tumor microenvironment.

Figure 6

(A) Representative images of MLH1 and MSH6 positive and negative tumors (original magnification, ×10). (B–E) ANOVA was used to compare microsatellite stable (MSS) (n = 64) and microsatellite instable (MSI) (n = 13) patients relative to infiltrating (B) T cells of total cells, (C) cytotoxic T lymphocytes (CTLs) of total cells, (D) CTLs as a percentage of T cells, and (E) PD-L1+ APCs of total APCs. (F) Comparison of CTL/EC engagement between MSS and MSI patients. (G) Kaplan-Meier survival curve for MSS and MSI patients. (H) Frequency of high PD-L1+ APCs (upper quartile) in MSS patients (n = 64) possessing MSI-like (n = 8) and non-MSI-like (n = 56) immune infiltrates.