Figure 4.

Venn diagrams showing the number of genes upregulated or downregulated significantly (q < 0.05) compared with the respective controls. (a) Of the 17,310 transcripts, 58 were changed significantly in the 12-day high Cort group compared with the sham-ADX group; 38 transcripts were upregulated, and 20 were downregulated. (b) In the 7-day ADX group, 43 transcripts were changed significantly; 9 were upregulated and 34 were downregulated. (c) Forty-seven transcripts were changed significantly either in the acute Cort (1) 1 h or acute Cort (1) 3 h groups compared with the noninjected control group (ADX + Cort suppl); 15 genes were upregulated and 32 were downregulated. (d) Forty-two transcripts were changed significantly in the acute Cort (1) 1 h group, and 14 were changed significantly in the acute Cort (1) 3 h group. Nine genes were affected at both 1 and 3 hours. (e) Of the 15 transcripts upregulated significantly by acute Cort injection, 11 were affected at 1 hour and 4 at 3 hours. (f) Of the 32 transcripts downregulated significantly by acute Cort injection, 31 were affected at 1 hour and 10 at 3 hours. Nine genes were affected at both 1 hour and 3 hours.