Table 1.
Transcripts Most Prominently Affected by Either the Long-Term Changes in Cort or Acute Cort Injection
| Upregulated | Downregulated | |||||
|---|---|---|---|---|---|---|
| Gene Symbol | Gene Product | Fold Change | Gene Symbol | Gene Product | Fold Change | |
| Experiment 1 | ||||||
| 12-day high Cort | Hif3a | Hypoxia-inducible factor 3-α | 7.00 | Crh | Corticotropin-releasing factor | 0.27 |
| Pla2g3 | Group 3 secretory phospholipase A2 | 4.61 | Fcrl2 | Fc receptor-like protein 2 | 0.29 | |
| Gpd1 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic | 3.73 | Pcdh12 | Protocadherin-12 | 0.30 | |
| LOC102723236 | 3.32 | Polq | DNA polymerase θ | 0.32 | ||
| Fmo2 | Dimethyaniline monooxygenase [N-oxide-forming] 2 | 3.16 | Mmp14 | Matrix metalloproteinase-14 | 0.40 | |
| Sgk1 | Serine/threonine-protein kinase Sgk1 | 2.77 | Cd93 | Compliment component C1q receptor | 0.45 | |
| Rn5-8s | 5.8S ribosomal RNA | 2.73 | Igf2 | Insulin-like growth factor 2 | 0.47 | |
| Ctgf | Connective tissue growth factor | 2.64 | Fabp7 | Fatty acid-binding protein, brain | 0.48 | |
| Sult1a1 | Sulfotransferase 1A1 | 2.56 | ||||
| Cd163 | Scavenger receptor cysteine-rich type 1 protein M130 | 2.52 | ||||
| Fst | Follistatin | 2.47 | ||||
| Gjb2 | Gap junction β-2 protein | 2.39 | ||||
| Slc19a3 | Thiamine transporter 2 | 2.24 | ||||
| Zbtb16 | Zinc finger and BTB domain-containing protein 16 | 2.12 | ||||
| LOC310926 | 2.12 | |||||
| Rn18s,Rn45s | 18S ribosomal RNA | 2.11 | ||||
| 7-day ADX | Crh | Corticotropin-releasing factor | 2.21 | RT1-N2 | 0.25 | |
| Clca1 | Calcium-activated chloride channel regulator 1 | 2.10 | Vip | Vasoactive intestinal polypeptide | 0.34 | |
| Ifit1 | Interferon-induced protein with tetratricopeptide repeats 1 | 0.38 | ||||
| Acsm5 | Acyl-coenzyme A synthetase ACSM5, mitochondrial | 0.39 | ||||
| Sult1a1 | Sulfotransferase 1A1 | 0.45 | ||||
| Gabrd | Gamma-aminobutyric acid receptor subunit δ | 0.49 | ||||
| Experiment 2 | ||||||
| Acute Cort (1) 1 h | Bsx | Brain-specific homeobox protein homolog | 2.60 | Rn5-8s | 5.8S ribosomal RNA | 0.18 |
| Nr4a3 | Nuclear receptor subfamily 4 group A member 3 | 2.58 | Mybpc1 | Myosin-binding protein C, slow-type | 0.27 | |
| Fos | Proto-oncogene c-Fos | 2.03 | LOC102723236 | 0.27 | ||
| Fosb | Protein fosB | 2.03 | Slc17a7 | Vesicular glutamate transporter 1 | 0.35 | |
| LOC310926 | 0.39 | |||||
| Rn18s,Rn45s | 18S ribosomal RNA | 0.42 | ||||
| Rn28s | 28S ribosomal RNA | 0.45 | ||||
| Wnt9b | Protein Wnt-9b | 0.46 | ||||
| Prkcd | Protein kinase C, δ type | 0.48 | ||||
| RGD1560028 | 0.48 | |||||
| Acute Cort (1) 3 h | LOC102723236 | 0.28 | ||||
| Rn5-8s | 5.8S ribosomal RNA | 0.29 | ||||
| LOC310926 | 0.38 | |||||
| Rn18s | 18S ribosomal RNA | 0.40 | ||||
| Slc17a7 | Vesicular glutamate transporter 1 | 0.42 | ||||
| Rn28s | 28S ribosomal RNA | 0.44 | ||||
| Mybpc | Myosin-binding protein C, slow-type | 0.49 | ||||
Transcripts significantly upregulated (more than twofold) or significantly downregulated (<0.5-fold) are listed in this table. See text for experimental procedures.