Table 1.

Quality assessment.

Author	Year	Design	PubMed ID	Study size	Treatment/ control	Dose	Duration
Altenburg et al.4	2013	RCT	23532241	83	A/P	250 mg once/day	52 weeks
Cymbala et al.24	2005	RCT	15813663	22	A/P	500 mg twice/week	6 months
Diego et al.25	2013	RCT	23714268	30	A/P	250 mg 3 times/week	3 months
Liu et al.26	2014	RCT	25580060	43	R/P	150 mg once/day	6 months
Serisier et al.2	2013	RCT	23532242	117	E/P	400 mg twice/day	48 weeks
Tsang et al.27	1999	RCT	10065682	21	E/P	500 mg twice/day	8 weeks
Wong et al.11	2012	RCT	22901887	141	A/P	500 mg 3 times/week	6 months

A: azithromycin; P: placebo; E: erythromycin; R: roxithromycin.