Table 3. SVR12 according to baseline patient characteristics and on-treatment HCV viral decline.
Characteristics | Patient (N = 273) | ||
---|---|---|---|
Patient No. | SVR12 (%) | 95% CI | |
Age, years | |||
< 60 | 85 | 94.1 | 87.0–97.5 |
≥ 60 | 188 | 97.9 | 94.7–99.2 |
Sex | |||
Female | 146 | 96.6 | 92.2–98.5 |
Male | 127 | 96.9 | 92.2–98.8 |
Treatment experience | |||
Naïve | 182 | 96.7 | 93.0–98.5 |
Experienced | 91 | 96.7 | 90.8–98.9 |
HBV coinfection | |||
Absent | 264 | 96.6 | 93.7–98.2 |
Present | 9 | 100 | 70.1–100 |
HIV coinfection | |||
Absent | 260 | 96.5 | 93.6–98.2 |
Present | 13 | 100 | 77.2–100 |
Prior HCC history | |||
Absent | 216 | 96.8 | 93.5–98.4 |
Present | 57 | 96.5 | 88.1–99.0 |
Liver transplantation | |||
No | 247 | 96.4 | 93.2–98.1 |
Yes | 26 | 100 | 87.1–100 |
Renal transplantation | |||
No | 260 | 96.5 | 93.6–98.2 |
Yes | 13 | 100 | 77.2–100 |
Treatment duration, week | |||
8 | 5 | 100 | 56.6–100 |
12 | 265 | 96.6 | 93.7–98.2 |
24 | 3 | 100 | 43.9–100 |
RBV usage | |||
No | 185 | 97.3 | 93.8–98.8 |
Yes | 88 | 95.5 | 88.9–98.2 |
eGFR, mL/min/1.73m2 | |||
< 60 | 52 | 98.1 | 89.9–99.7 |
≥ 60 | 221 | 96.4 | 93.0–98.2 |
HCV RNA, IU/mL | |||
< 6,000,000 | 225 | 96.4 | 93.1–98.2 |
≥ 6,000,000 | 48 | 97.9 | 89.1–99.6 |
HCV genotype | |||
1a | 21 | 90.5 | 71.1–97.4 |
1b | 242 | 97.9 | 95.3–99.1 |
1 | 10 | 80.0 | 49.0–94.3 |
Cirrhosis | |||
Absent | 138 | 97.8 | 93.8–99.3 |
Present | 135 | 95.6 | 90.7–98.0 |
Child-Pugh A | 109 | 97.3 | 92.2–99.1 |
Child-Pugh B and C | 26 | 88.5 | 71.0–96.0 |
Week 4 HCV RNA < LLOD* | |||
No | 54 | 94.4 | 84.9–98.1 |
Yes | 218 | 97.7 | 94.8–99.0 |
NA: not assessed.
* One patient who expired at treatment week 3 did not have week 4 HCV RNA data.