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. 2018 Dec 21;13(12):e0209299. doi: 10.1371/journal.pone.0209299

Table 3. SVR12 according to baseline patient characteristics and on-treatment HCV viral decline.

Characteristics Patient (N = 273)
Patient No. SVR12 (%) 95% CI
Age, years
 < 60 85 94.1 87.0–97.5
 ≥ 60 188 97.9 94.7–99.2
Sex
 Female 146 96.6 92.2–98.5
 Male 127 96.9 92.2–98.8
Treatment experience
 Naïve 182 96.7 93.0–98.5
 Experienced 91 96.7 90.8–98.9
HBV coinfection
 Absent 264 96.6 93.7–98.2
 Present 9 100 70.1–100
HIV coinfection
 Absent 260 96.5 93.6–98.2
 Present 13 100 77.2–100
Prior HCC history
 Absent 216 96.8 93.5–98.4
 Present 57 96.5 88.1–99.0
Liver transplantation
 No 247 96.4 93.2–98.1
 Yes 26 100 87.1–100
Renal transplantation
 No 260 96.5 93.6–98.2
 Yes 13 100 77.2–100
Treatment duration, week
 8 5 100 56.6–100
 12 265 96.6 93.7–98.2
 24 3 100 43.9–100
RBV usage
 No 185 97.3 93.8–98.8
 Yes 88 95.5 88.9–98.2
eGFR, mL/min/1.73m2
 < 60 52 98.1 89.9–99.7
 ≥ 60 221 96.4 93.0–98.2
HCV RNA, IU/mL
 < 6,000,000 225 96.4 93.1–98.2
 ≥ 6,000,000 48 97.9 89.1–99.6
HCV genotype
 1a 21 90.5 71.1–97.4
 1b 242 97.9 95.3–99.1
 1 10 80.0 49.0–94.3
Cirrhosis
 Absent 138 97.8 93.8–99.3
 Present 135 95.6 90.7–98.0
  Child-Pugh A 109 97.3 92.2–99.1
  Child-Pugh B and C 26 88.5 71.0–96.0
Week 4 HCV RNA < LLOD*
 No 54 94.4 84.9–98.1
 Yes 218 97.7 94.8–99.0

NA: not assessed.

* One patient who expired at treatment week 3 did not have week 4 HCV RNA data.