Table 1. Mutant alleles detected in the 188 deaf families and 47 normal-hearing controls.

Nucleotide change	Amino acid change	Allele no. in patients (%)#	Allele no. in controls (%)†
GJB2
c.-23+1G>A	NA	12 (3.2)	0 (0)
c.235delC	p.Leu79Cysfs*3	8 (2.1)	1 (1.1)
c.35delG	p.Gly12Valfs*2	6 (1.6)	0 (0)
c.109G>A	p.Val37Ile	4 (1.0)	0 (0)
c.299_300delAT	p.His100Argfs*14	4 (1.0)	0 (0)
c.35dupG	p.Val13Cysfs*35	2 (0.5)	0 (0)
c.560_605dup	p.Cys202*	2 (0.5)	0 (0)
c.269T>C	p.Leu90Pro	1 (0.3)	0 (0)
c.508_511dupAACG	p.Ala171Glufs*40	1 (0.3)	0 (0)
Total		40 (10.6)K	1 (1.1)K
SLC26A4
c.919-2A>G	NA	7 (2.1)	0 (0)
c.281C>T	p.Thr94Ile	1 (0.3)	0 (0)
c.2027T>A	p.Leu676Gln	1 (0.3)	0 (0)
Total		9 (2.4)	0 (0)
MT-RNR1
m.1555A>G	NA	2 (1.1)	0 (0)

^# 376 GJB2, 376 SLC26A4, and 188 MT-RNR1 alleles.

^† 94 GJB2, 94 SLC26A4, and 47 MT-RNR1 alleles.

^K p < 0.01 by Fisher’s exact test.

NA, Not available.