Table 3. Segregation Analysis of the DVL2 (DVL2c.2044delC) Variant with Vertebral Phenotype.
Thoracic Vertebral Malformation | Caudal Vertebral Malformation | ||||
---|---|---|---|---|---|
Breed | Genotype | Yes | No | Yes | No |
Boston Terrier | +/+ | 0 | 2 | 0 | 1 |
dvl2/+ | 0 | 2 | 0 | 2 | |
dvl2/ dvl2 | 20 | 24 | 12 | 0 | |
Shih Tzu | +/+ | 0 | 17 | 0 | 8 |
dvl2/+ | 0 | 1 | 0 | 1 | |
Pit Bull and Mixes | +/+ | 0 | 14 | 0 | 7 |
dvl2/+ | 0 | 5 | 0 | 3 | |
dvl2/ dvl2 | 0 | 2 | 4 | 0 | |
Fisher’s exact test | p = 1.5 X 10−5 | p = 4.5 X 10−11 |