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Four experimentally studied cases of the role of nucleic acid flexibility in model MLOs. ssDNAs with different persistence lengths are visualized at low and high salt. Droplets with rigid chains dissolve more easily than droplets with flexible chains. dsDNA forms aggregates at low salt and liquid droplets with liquid-crystalline ordering at high salt. Mixing DNA with free NTPs leads to subcompartments that contain the liquid-crystalline phase. To see this figure in color, go online.
