Figure 1.

The experimental permeability P_exp plotted against the respective hexadecane/water partition coefficients K_hd/w. P_exp was measured for 24 different anions through DPhPC bilayers, and K_hd/w (L_w and L_hd stand for litre water and litre hexadecane respectively) was calculated using the commercial prediction model COSMOtherm. The linear regression (n = 18; shaded circles) was made with IGOR Pro. Circles marked with a downward arrow indicate upper limits of P_exp and are not used for the regression. Because of its high solubility in water, P_exp for salicylate (lowest datapoint) could be determined.