Figure 5.

The permeability values from literature (P_lit) plotted against the respective partition coefficients K. Permeability is taken from literature for 19 different anions (see Table S7), and the anionic K-values are calculated using COSMOtherm. For validation, the linear regression determined for our own permeability data (dashed line; see Fig. 1) is plotted alongside literature data. Literature data measured for decane, heptane, or solvent depleted bilayers (open black squares) are plotted against the respective hexadecane/water partition coefficients, whereas literature data measured for chlorodecane bilayers are plotted against both the respective hexadecane/water partition coefficients (open gray diamonds) as well as the chlorodecane/water partition coefficients (open black diamonds). The respective shift to higher partition coefficients is marked by arrows. The fact that the latter data follow the correlation indicates that the solvent chlorodecane increases the dielectric constant in the membrane. The deviations from the correlation for the highest permeabilities may be due to overlooked saturation. Symbols marked with a downward/upward arrow indicate upper/lower limits of the permeability.