Figure 3.

Mechanical signal propagation in coculture samples. (A) The top shows bright-field images of soft, moderate, and stiff substrate samples (from left to right). The red arrowheads indicate the tested locations for each sample (scale bars, 100 μm). The bottom shows the beating force magnitude (nN) versus the CM-CMF boundary distance (μm) curves of the samples. Data are shown as mean, and the error bar represents the SD of the measured values; (B) the maximal propagating distances of control and coculture samples for soft, moderate, and stiff substrates. The percentages show the ratios of these distances, corresponding to each substrate stiffness; (C) ratios of CMF and CM contractile forces at the maximal transmitted distance for different substrate stiffness. To see this figure in color, go online.