Table 1.
Baseline characteristics of the study population
| Cases | Controls | All | OR [95%CI]a | P a | |
|---|---|---|---|---|---|
| All ages [N/mLOY] | 5772/1145 | 6732/918 | 12504/2063 | 1.332 [1.206; 1.472] | 1.60 × 10−08 |
| <65 years [N/mLOY] | 538/69 | 1735/172 | 2273/241 | 1.316 [0.969; 1.771] | 0.0738 |
| 65–70 years [N/mLOY] | 675/108 | 1228/122 | 1903/230 | 1.748 [1.321; 2.311] | 9.02 × 10−05 |
| 70–75 years [N/mLOY] | 1131/209 | 1376/190 | 2507/399 | 1.422 [1.147; 1.764] | 0.0013 |
| 75–80 years [N/mLOY] | 1478/268 | 1191/175 | 2669/443 | 1.282 [1.042; 1.580] | 0.0195 |
| >80 years [N/mLOY] | 1856/482 | 1161/255 | 3017/737 | 1.229 [1.034; 1.465] | 0.0201 |
| Ever smoked [%/N] | 74.58/1137 | 63.6/1022 | 69.38/2159 | 1.688 [1.397; 2.041] | 6.11 × 10−08 |
| Current smoker [%/N] | 16.57/519 | 8.39/691 | 11.9/1210 | 2.638 [1.804; 3.886] | 6.92 × 10−07 |
| Average pack-years (SD) | 27.39 (26.2) | 19.81 (23.88) | 25.09 (25.75) | 1.012 [1.006; 1.018] | 2.47 × 10−04 |
N number of samples, mLOY number of samples with mLOY, OR [95%] odds ratio and 95% confidence interval of association between cases and controls (mLOY or smoking status), P P value of association between cases and controls, SD standard deviation
aLogistic regression models adjusted for age and the first two principal components of ancestry as well as the AMD genetic risk score