Figure 2.

(A) Mean plasma concentration vs. time profiles of risdiplam following single oral doses of 0.6–18.0 mg in the fasted state (semi‐log scale). (B) Plasma concentration vs. time profiles of 6.0 mg risdiplam administered under fasted or fed conditions. (C) Plasma concentration vs. time profiles of risdiplam following single oral doses of 6.0 mg in the fed state alone or in combination with itraconazole (semi‐og scale). (D) Combined individual capillary vs. venous plasma concentrations of risdiplam. (A–C) Error bars represent standard deviation. BID, twice a day