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. 2018 Dec 21;8:18038. doi: 10.1038/s41598-018-36061-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mecom acts upstream of emx1 to regulate DL segment development. (A) WISH (lateral view) of 28 ss WT and emx1 deficient embryos for mecom (purple) and smyhc1 (red) expression. (B) Quantification of mecom domain length. (C) WISH of 28 ss WT and mecom deficient embryos for emx1 (purple) and smyhc1 (red). (D) Quantification of emx1 domain length. (E) WISH (lateral view) of 28 ss WT, mecom deficient, and mecom deficient embryos co-injected with emx1 capped mRNA (emx1 cRNA rescue) for the DL segment marker slc12a3 (purple). (A, C, E) Blue boxes demarcate domains of pronephros expression. Scale bar = 100 μm. (F) Quantification of DL length for WT, mecom deficient, and emx1 cRNA rescue embryos. (G) Quantification of phenotype percentages for (F), categorized as WT, decreased, or other, where the latter include those developmentally delayed or too dysmorphic to measure. **p < 0.01; ***p < 0.001; N.S. = not significant. Error bars represent standard error.