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. 2018 Dec 21;9:5416. doi: 10.1038/s41467-018-07901-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Comparison of CRISPRko and CRISPRi. a Comparison of AUCs for essential, non-essential and non-targeting sgRNAs across CRISPRko and CRISPRi libraries screened in A375 cells. CRISPRko is plotted as circular points and CRISPRi is plotted as triangles. b Comparison of the log2-fold change of genes in Brunello and Dolcetto (average of Sets A and B). Pearson correlation is reported. c Scatter plot comparing the GSEA normalized enrichment scores (NES) for KEGG genes sets for Brunello and Dolcetto. Selected gene sets are annotated. d Scatter plot comparing log2-fold change of genes from the KEGG Systemic Lupus Erythematosus gene set for Brunello and Dolcetto in A375 cells. Histone genes are colored based on their chromosomal location. e Segmented copy number (segment mean; log2-fold change from average) of genetic loci in A375 cells. f Position of gene start along chromosome 1 compared to the difference in log2-fold change between Brunello and Dolcetto in A375 cells. g Depletion of histone genes and essential genes in data from the Project Achilles screens in 369 cell lines screened with both RNAi and CRISPR (Avana library). The box represents the 25th, 50th, and 75th percentiles; whiskers show 10th and 90th percentiles